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Prednisone most often is used for treating several types of arthritis systemic lupus, allergic reactions, asthma and severe psoriasis. Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired. Prednisone and Prednisolone are members of the glucocorticoid class of hormones. Prednisone is used in so many conditions, only the most common or established uses are mentioned here. Do not stop using Prednisolone suddenly, or you could have unpleasant withdrawal symptoms.