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Topamax is an anticonvulsant that works in several ways to prevent seizures and migraines. Topiramate has been approved for migraine prophylaxis in many countries worldwide. It also is used to prevent migraine headaches. Topamax is being studied for use in weight loss and to help treat alcoholics. The duration and intensity of its effects. One of the medications that have been increasingly prescribed as a migraine preventive is the antiseizure medication Topamax. Topamax is used to prevent migraine headaches.