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Celecoxib does not interfere with the clotting of blood. Before taking Celecoxib, tell your doctor or pharmacist if you are already taking Celebrex, it is important to keep taking it as instructed by your doctor. Celebrex is used to treat arthritis, pain, menstrual cramps, and colonic polyps. In the treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. In osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.