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Celebrex is used to reduce pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celecoxib is a nonsteroidal anti-inflammatory drug that is used to decrease growths found in the intestines of persons with a family history of this condition. Celecoxib is a nonsteroidal anti-inflammatory drug that is used to decrease growths found in the intestines of persons with a family history of this condition. Celecoxib is a non-steroidal anti-inflammatory drug. Celecoxib does not prevent the progression of either type of arthritis. Before taking Celecoxib, tell your doctor or pharmacist if you are already taking Celebrex, it is important to keep taking it as instructed by your doctor. Celecoxib should only be used in pregnant women when the benefits outweigh the potential risk to the fetus. The action of a substance in the body by inhibiting the breakdown of Celecoxib in the body called cyclo-oxygenase.